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Search Results for " wnt pathway inhibitor 2 "

10

Compounds

Cat No. Product Name Synonyms Targets
T38519 YB-0158 Wnt pathway inhibitor 2,YB-0158
YB-0158 (Wnt pathway inhibitor 2) is a powerful peptidomimetic compound that effectively targets colorectal cancer stem cells (CSCs) by disrupting the interaction between Sam68 and Src proteins. This compound acts as a r...
T9557 TNIK-IN-2 Wnt/beta-catenin
TNIK-IN-2 is an inhibitor Traf2- and Nck-interacting protein kinase (TNIK, IC50 = 1.33 μM)) which is a downstream signal protein of the Wnt/β-catenin pathway.
T6768 AZ6102 PARP , Wnt/beta-catenin
AZ6102 is a potent TNKS1/2 inhibitor that has 100-fold selectivity against other PARP family enzymes and shows IC50 of 5 nM for Wnt pathway inhibition in DLD-1 cells.
T2310L CHIR-99021 HCl CT99021 HCl,Laduviglusib HCl GSK-3
CHIR-99021 HCl (Laduviglusib HCl) is a highly potent and selective inhibitor of GSK-3α/β, with IC50 values of 10 nM and 6.7 nM respectively. It demonstrates remarkable selectivity for GSK-3, with over 500-fold selectivit...
T5S0754 Isoquercetin 3-Glucosylquercetin,Hirsutrin,Isoquercitrin,Quercetin 3-o-glucopyranoside NF-κB , Wnt/beta-catenin , NO Synthase
1. Isoquercetin (3-Glucosylquercetin) is a potential stimulator of bone mineralization used for prophylaxis of osteoporotic disorders. 2. Isoquercetin may be as a potential therapeutic agent against neurodegeneration in ...
T69486 BMD4503-2
BMD4503-2 is an LRP5/6-sclerostin interaction inhibitor. BMD4503-2 recovers the downregulated activity of the Wnt/β-catenin signaling pathway by competitively binding to the LRP5/6-sclerostin complex.
T79810 Porcn-IN-2
Porcn-IN-2 (Example 107) is a potent Wnt pathway inhibitor, exhibiting an IC50 of 0.05 nM. It has applications in cancer research, including sarcoma, melanoma, skin cancer, hematological tumors, lymphoma, carcinoma, and ...
T78120 β-catenin-IN-6
β-Catenin-IN-6 is an inhibitor of the canonical Wnt/β-catenin signaling pathway, effectively impeding the proliferation of human colorectal cancer cells and demonstrating efficacy in a β-catenin/RK3E mouse model [1] [2].
T35547 YW1128
YW1128 is an inhibitor of Wnt/β-catenin signaling with an IC50 value of 4.1 nM in a reporter assay.1 It decreases protein levels of β-catenin in the presence of the GSK3β inhibitor lithium chloride and increases protein ...
T65994 (6S)-N-Benzyl-6-(4-hydroxybenzyl)-8-(naphthalen-1-ylmethyl)-4,7-dioxohexahydro-2H-pyrazino[1,2-a]pyrimidine-1(6H)-carboxamide
Wnt signaling is required for direct multiple biological processes and also plays key roles in the pathogenesis of various diseases. Cyclic AMP response element-binding protein (CREB) is a transcription factor that is a ...
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